Document Detail


Oscillations in cerebral haemodynamics in patients with falciparum malaria.
MedLine Citation:
PMID:  22879021     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spontaneous oscillations in cerebral haemodynamics studied with near-infrared spectroscopy (NIRS), become impaired in several pathological conditions. We assessed the spectral characteristics of these oscillations in 20 patients with falciparum malaria admitted to Ispat General Hospital, Rourkela, India. Monitoring included continuous frontal lobe NIRS recordings within 24 h of admission (Day 0), together with single measurements of a number of clinical and chemical markers recorded on admission. Seven patients returned for follow-up measurements on recovery (FU). A 2,048 sampling-point segment of oxygenated haemoglobin concentration ([ΔHbO(2)]) data was subjected to Fourier analysis per patient, and power spectral density was derived over the very low frequency (VLF: 0.02-0.04 Hz), low frequency (LF: 0.04-0.15 Hz) and high frequency (HF: 0.15-0.4 Hz) bands. At Day 0, VLF spectral power was 21.1 ± 16.4, LF power 7.2 ± 4.6 and HF power 2.6 ± 5.0, with VLF power being statistically significantly higher than LF and HF (P < 0.005). VLF power tended to decrease in the severely ill patients and correlated negatively with heart rate (r = 0.57, P < 0.01), while LF power correlated positively with aural body temperature (r = 0.49, P < 0.05). In all but one of the patients who returned for FU measurements, VLF power increased after recovery. This may be related to autonomic dysfunction in severe malaria, a topic of little research to date. The present study demonstrated that application of NIRS in a resource-poor setting is feasible and has potential as a research tool.
Authors:
Christina Kolyva; Hugh Kingston; Ilias Tachtsidis; Sanjib Mohanty; Saroj Mishra; Rajya Patnaik; Richard J Maude; Arjen M Dondorp; Clare E Elwell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  765     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-10     Completed Date:  2012-12-11     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain / blood supply*,  physiopathology
Cerebrovascular Circulation / physiology*
Electrocardiography
Fourier Analysis
Heart Rate*
Hemodynamics / physiology*
Humans
India
Malaria, Falciparum / physiopathology*
Male
Middle Aged
Plasmodium falciparum / pathogenicity
Signal Processing, Computer-Assisted
Spectroscopy, Near-Infrared*
Young Adult
Grant Support
ID/Acronym/Agency:
G0701458//Medical Research Council; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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