| Oscillations in cardiovascular function during acute hypoxia in the newborn piglet are associated with less neurological damage and occur more frequently in females. | |
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MedLine Citation:
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PMID: 19190542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The function of the cardiovascular system during hypoxia is an important determinant of neurologic outcome. Oscillations in blood pressure, particularly type-3 waves with a duration of 10 to 160 s, have been shown to occur in the presence of hypoxia in the neonatal rat. The aim of this study was to determine the characteristics and occurrence of type-3 waves in the neonatal piglet and any relationship to neurologic damage after acute global hypoxia. Hypoxia/hypercarbia was induced in 32 anesthetized piglets by reducing the fraction of inspired oxygen to 0.1 and the ventilation rate from 30 to 10 breaths per minute for 45 min. The degree of neurologic damage was assessed using both physiologic (EEG amplitude and cerebral impedance at 6 h posthypoxia) and structural (microtubule associated protein-2 immunohistochemistry) markers. Type-3 waves in cardiovascular function occurred in 56% of animals. An oscillating pattern was significantly associated with less neurologic damage (p = 0.01) and a lower duration of hypotension during hypoxia (p = 0.02), and occurred more frequently in females (p = 0.024). |
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Authors:
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Thomas A Harris; Genevieve N Healy; Paul B Colditz; Barbara E Lingwood |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pediatric research Volume: 65 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-07-21 Completed Date: 2009-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 504-8 Citation Subset: IM |
Affiliation:
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Perinatal Research Centre, University of Queensland Centre for Clinical Research, The University of Queensland, Royal Brisbane and Women's Hospital, Queensland, Australia 4029. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Animals, Newborn Anoxia / complications, pathology, physiopathology* Biological Markers / metabolism Blood Pressure Cardiovascular System / physiopathology* Cerebrovascular Circulation Disease Models, Animal Electroencephalography Female Heart Rate Hemodynamics* Hypoxia, Brain / etiology*, pathology, physiopathology Immunohistochemistry Male Microtubule-Associated Proteins / metabolism Neurons / metabolism, pathology* Periodicity Regional Blood Flow Severity of Illness Index Sex Factors Skin / blood supply Swine |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Microtubule-Associated Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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