Document Detail


Oscillations in cardiovascular function during acute hypoxia in the newborn piglet are associated with less neurological damage and occur more frequently in females.
MedLine Citation:
PMID:  19190542     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The function of the cardiovascular system during hypoxia is an important determinant of neurologic outcome. Oscillations in blood pressure, particularly type-3 waves with a duration of 10 to 160 s, have been shown to occur in the presence of hypoxia in the neonatal rat. The aim of this study was to determine the characteristics and occurrence of type-3 waves in the neonatal piglet and any relationship to neurologic damage after acute global hypoxia. Hypoxia/hypercarbia was induced in 32 anesthetized piglets by reducing the fraction of inspired oxygen to 0.1 and the ventilation rate from 30 to 10 breaths per minute for 45 min. The degree of neurologic damage was assessed using both physiologic (EEG amplitude and cerebral impedance at 6 h posthypoxia) and structural (microtubule associated protein-2 immunohistochemistry) markers. Type-3 waves in cardiovascular function occurred in 56% of animals. An oscillating pattern was significantly associated with less neurologic damage (p = 0.01) and a lower duration of hypotension during hypoxia (p = 0.02), and occurred more frequently in females (p = 0.024).
Authors:
Thomas A Harris; Genevieve N Healy; Paul B Colditz; Barbara E Lingwood
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  65     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  504-8     Citation Subset:  IM    
Affiliation:
Perinatal Research Centre, University of Queensland Centre for Clinical Research, The University of Queensland, Royal Brisbane and Women's Hospital, Queensland, Australia 4029.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Animals, Newborn
Anoxia / complications,  pathology,  physiopathology*
Biological Markers / metabolism
Blood Pressure
Cardiovascular System / physiopathology*
Cerebrovascular Circulation
Disease Models, Animal
Electroencephalography
Female
Heart Rate
Hemodynamics*
Hypoxia, Brain / etiology*,  pathology,  physiopathology
Immunohistochemistry
Male
Microtubule-Associated Proteins / metabolism
Neurons / metabolism,  pathology*
Periodicity
Regional Blood Flow
Severity of Illness Index
Sex Factors
Skin / blood supply
Swine
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Microtubule-Associated Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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