| Oscillations of granulocytic and megakaryocytic progenitor cell populations in cyclic neutropenia in man. | |
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MedLine Citation:
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PMID: 493869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The concentration of granulocytic progenitor cells in the bone marrow of 2 patients with cyclic neutropenia was assessed at intervals during the cycle. Syncroneous oscillations were observed for cells forming neutrophilic and megakaryocytic colonies in diffusion chambers in vivo (CFU-D), suggesting a close relationship between the two cell types. However, an almost reverse relationship was observed between CFU-D and cells forming colonies in agar culture in vitro (CFU-C), which cycled out of phase with CFU-D. This supports the concept that CFU-D and CFU-C denote different cell types. |
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Authors:
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N Jacobsen; H E Broxmeyer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Scandinavian journal of haematology Volume: 23 ISSN: 0036-553X ISO Abbreviation: Scand J Haematol Publication Date: 1979 Jul |
Date Detail:
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Created Date: 1979-12-20 Completed Date: 1979-12-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404507 Medline TA: Scand J Haematol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 33-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Agranulocytosis
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blood* Cells, Cultured Colony-Forming Units Assay Granulocytes / physiology* Hematopoiesis* Hematopoietic Stem Cells / physiology* Humans Leukocyte Count Megakaryocytes / physiology* Neutropenia / blood* |
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