Document Detail

Oscillations of granulocytic and megakaryocytic progenitor cell populations in cyclic neutropenia in man.
MedLine Citation:
PMID:  493869     Owner:  NLM     Status:  MEDLINE    
The concentration of granulocytic progenitor cells in the bone marrow of 2 patients with cyclic neutropenia was assessed at intervals during the cycle. Syncroneous oscillations were observed for cells forming neutrophilic and megakaryocytic colonies in diffusion chambers in vivo (CFU-D), suggesting a close relationship between the two cell types. However, an almost reverse relationship was observed between CFU-D and cells forming colonies in agar culture in vitro (CFU-C), which cycled out of phase with CFU-D. This supports the concept that CFU-D and CFU-C denote different cell types.
N Jacobsen; H E Broxmeyer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Scandinavian journal of haematology     Volume:  23     ISSN:  0036-553X     ISO Abbreviation:  Scand J Haematol     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404507     Medline TA:  Scand J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
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MeSH Terms
Agranulocytosis / blood*
Cells, Cultured
Colony-Forming Units Assay
Granulocytes / physiology*
Hematopoietic Stem Cells / physiology*
Leukocyte Count
Megakaryocytes / physiology*
Neutropenia / blood*

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