Document Detail


Oscillations of fatty acid and glycerol release from human subcutaneous adipose tissue in vivo.
MedLine Citation:
PMID:  15855313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We sought evidence for pulsatility of lipolysis in human subcutaneous adipose tissue in vivo. Arterialized and adipose tissue venous blood samples were drawn at 2-min intervals from nine healthy subjects. This procedure was repeated during hyperinsulinemic-euglycemic clamp to remove insulin pulsatility. We found evidence for pulsatile release of both nonesterified fatty acids (NEFAs) (seven of nine subjects) and glycerol (five of six subjects) with a period of approximately 12-14 min. This pulsatility was maintained even during the hyperinsulinemic clamp. Checks were made for spurious pulse detection, including the creation of "mock" venoarterialized differences by subtracting one subject's arterialized concentrations from another's venous; the peaks detected were less consistent in character than with real data (peak width, P = 0.006; peak interval, P < 0.004). Significant cross-correlations between NEFA and glycerol release also provided evidence of a real effect. Arterialized norepinephrine concentrations were also pulsatile, but the period did not match that of NEFA and glycerol release. Insulin concentrations were pulsatile with a typical period of 12 min, but this was not significantly cross-correlated with lipolysis. We conclude that release from adipose tissue of the products of lipolysis is pulsatile in humans.
Authors:
Fredrik Karpe; Barbara A Fielding; Simon W Coppack; Victor J Lawrence; Ian A Macdonald; Keith N Frayn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes     Volume:  54     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-27     Completed Date:  2005-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1297-303     Citation Subset:  AIM; IM    
Affiliation:
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Adult
Blood Glucose / metabolism
Fatty Acids, Nonesterified / blood,  metabolism*
Female
Glucose / metabolism
Glycerol / blood,  metabolism*
Humans
Kinetics
Lipolysis / physiology*
Male
Middle Aged
Norepinephrine / blood,  metabolism
Regional Blood Flow
Reproducibility of Results
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 50-99-7/Glucose; 51-41-2/Norepinephrine; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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