Document Detail

Orthotopic heart transplantation for complex congenital heart disease.
MedLine Citation:
PMID:  2308366     Owner:  NLM     Status:  MEDLINE    
Orthotopic heart transplantation has become standard therapy for end-stage cardiomyopathy in children and adults, but there has been much less experience with transplantation for complex congenital heart disease. In this report experience with orthotopic transplantation in seven children with various forms of complex congenital heart disease is reviewed. Diagnoses included hypoplastic left heart syndrome in two (after stage I palliation), left ventricular diverticulum in one, single ventricle in two (dextrocardia, atrial situs inversus, and total anomalous pulmonary venous return in one patient and post-Fontan repair in the second), D-transposition of the great arteries and ventricular septal defect (post-Senning repair and ventricular septal defect closure) in one, and Ebstein's anomaly with biventricular dysplasia in one. Six of the seven were hospital survivors and there has been one late death at 2 1/3 years. Modifications of the standard operative technique to fit the anatomic variations in these defects are reviewed.
J E Mayer; S Perry; P O'Brien; A Perez-Atayde; R A Jonas; A R Castaneda; I A Parness
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  99     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-06     Completed Date:  1990-04-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  484-91; discussion 491-2     Citation Subset:  AIM; IM    
Department of Cardiovascular Surgery, Children's Hospital, Harvard Medical School, Boston, Mass.
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MeSH Terms
Blood Pressure
Cardiac Output
Child, Preschool
Cyclosporins / administration & dosage
Follow-Up Studies
Graft Rejection
Heart Defects, Congenital / surgery*
Heart Transplantation* / methods
Myocardium / pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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