Document Detail

Orthostatic tremor arises from an oscillator in the posterior fossa.
MedLine Citation:
PMID:  11295780     Owner:  NLM     Status:  MEDLINE    
We tested the hypotheses that orthostatic tremor is generated by a central oscillator and that the tremor is expressed through spinal Ib interneurons. Six patients with orthostatic tremor were examined. The tremor was reset by electrical stimulation over the posterior fossa at intensities that were below the threshold for a motor evoked potential (MEP) but was not reset by transcranial magnetic stimulation over the motor cortex that did produce an MEP. It is argued that the oscillator involves the cerebellum or brainstem. The inhibition of voluntary EMG produced by stimulation over tendons, which has been attributed to effects from Golgi tendon organs (GTO), was not modulated in synchrony with the tremor. We were unable to demonstrate, therefore, that the tremor is expressed through GTO interneurons with this method.
Y R Wu; P Ashby; A E Lang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  16     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-11     Completed Date:  2001-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  272-9     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Movement Disorder Society.
Second Department of Neurology, Chang-Gung Memorial Hospital, Taipei, Taiwan.
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MeSH Terms
Aged, 80 and over
Brain Stem / physiopathology
Cerebellum / physiopathology
Cranial Fossa, Posterior*
Electric Stimulation / methods
Electromyography / methods
Evoked Potentials, Motor / physiology
Hypotension, Orthostatic / complications,  diagnosis,  physiopathology*
Interneurons / physiology
Mechanoreceptors / physiology
Middle Aged
Motor Cortex / physiopathology
Motor Neurons / physiology
Neural Inhibition / physiology
Synaptic Transmission / physiology
Tremor / complications,  diagnosis,  physiopathology*
Vestibule, Labyrinth / physiology

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