| Orthostatic hypotension (OH) and mortality in relation to age, blood pressure and frailty. | |
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MedLine Citation:
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PMID: 22240412 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Systolic hypertension and OH, as with many other deficits, accumulate with age. This deficit accumulation results in frailty: enhanced vulnerability to adverse outcomes. This study evaluated OH in relation to age, frailty, systolic hypertension, and mortality. In the population-based Canadian Study of Health and Aging second clinical examination, complete data were available on 1347 people, mean age=83.3 (SD=6.4)years. A frailty index (FI) was calculated from a 52-item Comprehensive Geriatric Assessment (CGA), yielding an FI-CGA from 0 (no deficits) to 1.0 (52 deficits). The mean change in blood pressure from lying to standing was 7.3±15.6mmHg (range +94 to -60). In total, 239 people (17.7%) had OH (change >20mmHg systolic or >10mmHg diastolic). Mean systolic blood pressure was higher (155.8±23.3mmHg) in people with OH than in those without (141.4±23mmHg), as was the FI-CGA (0.18 vs. 0.16). OH increased with frailty and systolic hypertension, but not age. Unadjusted, OH was associated with an increased risk of death (relative risk=1.21, 95% confidence interval 1.19-1.23). Adjusted for frailty, this result was not significant. OH may be a marker of the system dysregulation seen in frailty, but as a state variable is a less powerful marker of vulnerability than is the FI-CGA. |
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Authors:
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Michael R H Rockwood; Susan E Howlett; Kenneth Rockwood |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
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Title: Archives of gerontology and geriatrics Volume: - ISSN: 1872-6976 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214379 Medline TA: Arch Gerontol Geriatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Division of Geriatric Medicine, Dalhousie University, Faculty of Medicine, Halifax, Nova Scotia, Canada B3H 4R2. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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