Document Detail

Orthostatic heart rate variability analysis in idiopathic Parkinson's disease.
MedLine Citation:
PMID:  16629763     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We evaluated time and spectral analyses of 24-h heart rate variability (HRV) and the heart rate responses to passive tilt in patients with idiopathic Parkinson's disease (IPD) in order to investigate cardiovascular autonomic functions. MATERIAL AND METHODS: Twenty-three subjects with IPD without autonomic symptoms and 15 age-matched healthy controls were enrolled. Frequency- and time-domain HRV parameters were studied during resting and passive head-up tilt (HUT) test. RESULTS: All time-domain parameters were found to be low in patients with IPD. In patients with IPD, both low frequency (LF) and high frequency (HF) decreased during HUT period and no significant change in LF to HF ratio was noted. Both time- and frequency-domain HRV indices showed no correlation with age, disease severity and duration, and with l-dopa medication. CONCLUSION: The results indicate that impairment of autonomic nervous system function in IPD without autonomic symptoms is frequent, and does not show clear association with clinical stage and the age of the patients.
E Mihci; F Kardelen; B Dora; S Balkan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  113     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-24     Completed Date:  2006-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  288-93     Citation Subset:  IM    
Department of Neurology, Akdeniz University School of Medicine, Antalya, Turkey.
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MeSH Terms
Age Factors
Antiparkinson Agents / administration & dosage
Autonomic Nervous System / physiopathology
Case-Control Studies
Heart Rate / physiology*
Levodopa / administration & dosage
Middle Aged
Parkinson Disease / drug therapy,  physiopathology*
Severity of Illness Index
Tilt-Table Test
Time Factors
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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