Document Detail

Orthostatic challenge reveals impaired vascular resistance control, but normal venous pooling and capillary filtration in familial dysautonomia.
MedLine Citation:
PMID:  12546638     Owner:  NLM     Status:  MEDLINE    
Patients with familial dysautonomia (FD) frequently have profound orthostatic hypotension without compensatory tachycardia. Although the aetiology is presumed to be sympathetic impairment, peripheral vascular responses to orthostasis have not been assessed. The aim of this study was to evaluate the control of vascular responses to postural stress in FD patients. Measurements of heart rate, blood pressure, cardiac stroke volume and cardiac output (CO), by impedance cardiography, and calf-volume changes, by impedance plethysmography, were taken from nine FD patients and 11 control subjects while supine and during head-up tilt. During leg lowering, we also assessed the venoarteriolar reflex by measuring skin red-cell flux. Head-up tilting for 10 min induced sustained decreases in mean arterial pressure in the FD patients, but not in the controls. Total peripheral resistance (TPR, i.e. mean arterial pressure/CO) increased significantly in the controls (39.8+/-6.8%), but not in the FD patients. Calf-volume changes during tilting, when normalized for the initial calf volume, did not differ significantly between the patients (4.62+/-1.99 ml.100 ml(-1)) and the controls (3.18+/-0.74 ml.100 ml(-1)). The vasoconstrictor response to limb lowering was present in the patients (47.7+/-9.0% decrease in skin red-cell flux), but was impaired as compared with the controls (80.7+/-3.4%) ( P <0.05). The impaired vasoconstriction during limb lowering and absent increase of TPR during tilting confirm that orthostatic hypotension in FD is due primarily to a lack of sympathetically mediated vasoconstriction without evidence of abnormally large shifts in blood volume towards the legs during orthostasis. This may be due, in part, to a preserved myogenic response to increased vascular pressure in the dependent vascular beds.
Clive M Brown; Brigitte Stemper; Götz Welsch; Miroslaw Brys; Felicia B Axelrod; Max J Hilz
Related Documents :
12357278 - Acute effect of water on blood pressure. what do we know?
22072108 - Hypothalamic gene expression in ω-3 pufa-deficient male rats before, and following, de...
13680148 - Cardiovascular reactivity score for the assessment of dysautonomia in familial mediterr...
10866698 - Norepinephrine and epinephrine responses during orthostatic intolerance in healthy elde...
2222958 - Studies of salt intake in hypertension. what can epidemiology teach us?
1506368 - Influence of lung volume and alveolar pressure on reverse pulmonary venous blood flow.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  104     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-27     Completed Date:  2003-03-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  163-9     Citation Subset:  IM    
Autonomic Laboratory, Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Capillary Permeability
Dysautonomia, Familial / complications*,  physiopathology
Hypotension, Orthostatic / etiology*,  physiopathology
Leg / blood supply
Regional Blood Flow
Supine Position
Tilt-Table Test
Vascular Resistance*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selecti...
Next Document:  Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activat...