Document Detail

Orthopaedic manifestations of blastomycosis.
MedLine Citation:
PMID:  2365718     Owner:  NLM     Status:  MEDLINE    
The cases of seventy-two patients who had blastomycosis and were seen between 1926 and 1988 were retrospectively reviewed for involvement of the musculoskeletal system. Most patients were from rural rather than urban areas (almost a 2:1 ratio), and an especially large number were from northwestern Ontario or were native Indians (primarily Ojibwa). Bone was the second most common site of involvement (seventeen patients); in approximately one-half of these patients, the osseous site did not cause symptoms. Metaphyses of long bones and small bones were involved the most; the metaphyseal lesions tended to be eccentric, well circumscribed, and lytic. There were two deaths--the most recent, more than twenty years ago--of patients who had involvement of bones and joints; these patients, by modern standards, had had inadequate treatment. Treatment with amphotericin B and, more recently, with ketoconazole, in conjunction with operative treatment, was very effective.
P B MacDonald; G B Black; R MacKenzie
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of bone and joint surgery. American volume     Volume:  72     ISSN:  0021-9355     ISO Abbreviation:  J Bone Joint Surg Am     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-16     Completed Date:  1990-08-16     Revised Date:  2010-10-25    
Medline Journal Info:
Nlm Unique ID:  0014030     Medline TA:  J Bone Joint Surg Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  860-4     Citation Subset:  AIM; IM    
Department of Surgery, University of Manitoba, Winnipeg, Canada.
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MeSH Terms
Amphotericin B / therapeutic use
Arthritis, Infectious / etiology
Blastomycosis / drug therapy,  radiography*
Ketoconazole / therapeutic use
Middle Aged
Osteomyelitis / drug therapy,  etiology*,  radiography
Retrospective Studies
Reg. No./Substance:
1397-89-3/Amphotericin B; 65277-42-1/Ketoconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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