| Orthogonal micro-organization of orientation and spatial frequency in primate primary visual cortex. | |
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MedLine Citation:
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PMID: 23143516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Orientation and spatial frequency tuning are highly salient properties of neurons in primary visual cortex (V1). The combined organization of these particular tuning properties in the cortical space will strongly shape the V1 population response to different visual inputs, yet it is poorly understood. In this study, we used two-photon imaging in macaque monkey V1 to demonstrate the three-dimensional cell-by-cell layout of both spatial frequency and orientation tuning. We first found that spatial frequency tuning was organized into highly structured maps that remained consistent across the depth of layer II/III, similarly to orientation tuning. Next, we found that orientation and spatial frequency maps were intimately related at the fine spatial scale observed with two-photon imaging. Not only did the map gradients tend notably toward orthogonality, but they also co-varied negatively from cell to cell at the spatial scale of cortical columns. |
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Authors:
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Ian Nauhaus; Kristina J Nielsen; Anita A Disney; Edward M Callaway |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-11-11 |
Journal Detail:
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Title: Nature neuroscience Volume: 15 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-28 Completed Date: 2013-01-29 Revised Date: 2013-05-13 |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 1683-90 Citation Subset: IM |
Affiliation:
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Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Macaca fascicularis Macaca radiata Orientation / physiology* Photic Stimulation / methods Spatial Behavior / physiology* Time Factors Visual Cortex / physiology* Visual Pathways / physiology |
| Grant Support | |
ID/Acronym/Agency:
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EY-010742/EY/NEI NIH HHS; EY-019821/EY/NEI NIH HHS; F32 EY019821/EY/NEI NIH HHS; F32 EY021122/EY/NEI NIH HHS; K99 MH093567/MH/NIMH NIH HHS; MH093567/MH/NIMH NIH HHS; R01 EY010742/EY/NEI NIH HHS |
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