Document Detail


Orotic acid-induced metabolic changes in the rat.
MedLine Citation:
PMID:  7365548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of orotic acid consumption on hepatic lipid and nucleotide metabolism were examined concurrently in the rat. When orotic acid was fed at 1.0%, fatty liver development was evident by day 7 but not by day 3, whereas a decreased purine/pyrimidine ratio of hepatic acid-soluble nucleotides was noted by day 3. As nucleotide changes preceded hepatic fat accumulation, they could be a contributing factor in the etiology of fatty liver. When fed for 10 days, rats did not accumulate hepatic fat on a diet containing 0.1%, but did on 0.5 and 1.0%; similarly, the purine/pyrimidine ratio was not significantly affected on 0.1% but was decreased on both 0.5 and 1.0% orotic acid. These results indicate that orotic acid alters both hepatic lipid and nucleotides when consumed by rats at a level above 0.1%. As measured in these studies, hepatomegaly did not always accompany hepatic steatosis and appeared to be a subsequent development. In addition, L-dihydroorotate was shown to be as effective as orotic acid in increasing hepatic weight and lipid whereas uridine was ineffective.
Authors:
R P Durschlag; J L Robinson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  110     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  816-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Female
Lipid Metabolism*
Liver / anatomy & histology,  metabolism*
Nucleotides / metabolism*
Organ Size
Orotic Acid / analogs & derivatives,  pharmacology*
Purines / metabolism
Pyrimidines / metabolism
Rats
Uridine / pharmacology
Chemical
Reg. No./Substance:
0/Nucleotides; 0/Purines; 0/Pyrimidines; 155-54-4/4,5-dihydroorotic acid; 58-96-8/Uridine; 65-86-1/Orotic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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