| Oropharyngeal administration of colostrum to extremely low birth weight infants: theoretical perspectives. | |
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MedLine Citation:
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PMID: 18769379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies in adults have shown that the oropharyngeal route can be used to effectively and safely administer interferon-alpha, an immune cell-derived cytokine, to patients who are unable to tolerate its parenteral administration. The mechanism for this appears to be the stimulatory effects of the cytokine, on the oropharyngeal-associated lymphoid tissue system. Own mother's colostrum (OMC) is rich in cytokines and other immune agents that provide bacteriostatic, bacteriocidal, antiviral, anti-inflammatory and immunomodulatory protection against infection. OMC may be especially protective for the extremely low birth weight (ELBW) infant in the first days of life; however clinical instability typically precludes enteral feedings during this period. Oropharyngeal administration is a potential alternative method of providing OMC. Oropharyngeal administration of OMC may have immunomodulatory effects on the recipient infant, and would be especially beneficial to the ELBW infant who would otherwise remain nil per os during the first days of life. |
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Authors:
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N A Rodriguez; P P Meier; M W Groer; J M Zeller |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2008-09-04 |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 29 ISSN: 1476-5543 ISO Abbreviation: J Perinatol Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-29 Completed Date: 2009-04-23 Revised Date: 2011-04-15 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Infant Special Care Unit, Department of Pediatrics, Evanston Hospital, Evanston Northwestern Healthcare, Evanston, IL 60201, USA. nrodriguez@enh.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Colostrum / immunology* Humans Infant, Low Birth Weight / immunology* Infant, Newborn |
| Grant Support | |
ID/Acronym/Agency:
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F31 NR007584-05/NR/NINR NIH HHS; F31NR007584/NR/NINR NIH HHS; NR010009/NR/NINR NIH HHS; R01 NR010009-02/NR/NINR NIH HHS; R01 NR010009-05/NR/NINR NIH HHS |
| Comments/Corrections | |
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