Document Detail

Orofacial granulomatosis: presentation, pathology and management of 13 cases.
MedLine Citation:
PMID:  14632932     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Orofacial granulomatosis (OFG) comprises of a group of conditions, all characterized histologically by the presence of granulomatous inflammation. METHODS: This diagnosis may be determined by exclusion from other conditions that may present with similar clinical and histopathologic features. These include Melkersson-Rosenthal syndrome (MRS), Miescher's cheilitis (an oligosymptomatic form of MRS), Crohn's disease, and sarcoidosis. RESULTS: A great deal of attention has been devoted to the similarity and overlap in clinicopathologic and histomorphologic features of these conditions, suggesting that they may actually represent a spectrum within a single overarching entity. In the review of the 13 cases of OFG retrieved from the files of the Long Island Jewish Medical Center, Department of Dental Medicine, we describe their presentation, clinicopathologic features, and management. These cases comprise examples of MRS (in its oligosymptomatic forms) and Crohn's disease. The similarity, kinship, and overlap between the cases presented are clearly demonstrated. CONCLUSION: In addition, based upon our observations and review, we propose the notion that oral manifestations of Crohn's disease may be classified as an oligosymptomatic form of MRS.
James J Sciubba; Nasser Said-Al-Naief
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  32     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-24     Completed Date:  2003-12-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  576-85     Citation Subset:  D; IM    
Department of Otolaryngology, Head & Neck Surgery, Division of Dental & Oral Medicine, John Hopkins School of Medicine, Baltimore, Maryland 21287, USA.
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MeSH Terms
Aged, 80 and over
Cheilitis / diagnosis
Crohn Disease / diagnosis,  pathology
Diagnosis, Differential
Granuloma / diagnosis*,  pathology,  therapy
Melkersson-Rosenthal Syndrome / diagnosis,  pathology
Middle Aged
Mouth Diseases / diagnosis*,  pathology,  therapy
Retrospective Studies
Sarcoidosis / diagnosis
Comment In:
J Oral Pathol Med. 2004 Apr;33(4):252   [PMID:  15061717 ]

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