Document Detail

Orofacial dyskinesia after moxifloxacin treatment-a case with normal hepatorenal function and review of literature.
MedLine Citation:
PMID:  23151468     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Orofacial dyskinesia is rarely reported with antibiotics. Among antibiotics, third-generation fluoroquinolones are known to cause movement disorders. We report the first patient who developed orofacial dyskinesia after taking a fourth-generation fluoroquinolone, namely, moxifloxacin.
METHODS: The patient is a 58-year-old woman who was treated with moxifloxacin for acute bronchitis. She developed orofacial dyskinesia involving the tongue, lips, and facial muscles after treatment.
RESULTS: Discontinuation of moxifloxacin and treatment with clonidine resulted in significant reduction of orofacial dyskinesia over the period of 8 to 12 weeks. A review of literature shows reports of a variety of involuntary movements with third-generation fluoroquinolones, mostly manifesting in patients with impaired renal and kidney function.
CONCLUSIONS: The fourth-generation fluoroquinolone moxifloxacin can cause orofacial dyskinesia like third-generation fluoroquinolone antibiotics and in a patient with normal renal and liver function.
Shivam Om Mittal; Duarte Goncalves Machado; Bahman Jabbari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  35     ISSN:  1537-162X     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-4     Citation Subset:  IM    
Department of Neurology, Yale University School of Medicine, New Haven, CT.
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