| Orofacial apraxia in corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy and Parkinson's disease. | |
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MedLine Citation:
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PMID: 15592726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine whether the assessment of orofacial praxis is useful for the differential diagnosis of parkinsonian syndromes and to understand the neural mechanisms underlying OFA, searching for the respective roles of cortical and subcortical structures. METHODS: Forty-four patients were assessed: 12 with idiopathic Parkinson's disease (IPD), 8 with multiple system atrophy (MSA), 12 with progressive supranuclear palsy (PSP) and 12 with corticobasal degeneration (CBD). An easy bedside scale was used, exploring single gestures, gestures with noise production and multiple sequential gestures. We searched for group and task effects. RESULTS: Patients with CBD were significantly more impaired than those with IPD, MSA or PSP (p<0.001). Our assessment was unable to distinguish between the IPD, MSA and PSP groups. There was a clear task effect in CBD with a major impairment in multiple sequential gestures (p<0.0001). CONCLUSION: Assessment of orofacial praxis helps in the clinical diagnosis of CBD. Patients with IPD, MSA and PSP did not present with OFA. We suggest that the deficit in multiple sequential gestures in CBD is related to simultaneous lesions of the parietal lobule and the supplementary motor area. |
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Authors:
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Canan Ozsancak; Pascal Auzou; Kathy Dujardin; Niall Quinn; Alain Destée |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of neurology Volume: 251 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-12-13 Completed Date: 2005-03-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 1317-23 Citation Subset: IM |
Affiliation:
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Service de Neurologie et Pathologie du Mouvement, EA 2683 Clinique Neurologique, CHU de Lille, 59037, Lille Cedex, France. c_ozsancak@yahoo.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Apraxias / etiology* Basal Ganglia Diseases / diagnosis, physiopathology* Diagnosis, Differential Female Humans Male Middle Aged Movement Multiple System Atrophy / physiopathology* Multivariate Analysis Neurodegenerative Diseases / physiopathology Neurologic Examination / methods Neuropsychological Tests Olfaction Disorders / etiology Parkinson Disease / diagnosis, physiopathology* Supranuclear Palsy, Progressive / diagnosis, physiopathology* |
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