| Ornithine decarboxylase lability in 2 transplantable highly deviated rat hepatomas. | |
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MedLine Citation:
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PMID: 3581055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A strong ornithine decarboxylase (ODC)-inactivating capacity has been previously shown (M.F. Zuretti and E. Gravela (1983) Biochim. Biophys. Acta, 742, 269-277) to be bound to rat liver microsomes. Present results show that in 2 fast-growing transplantable tumors, the 3924A Morris hepatoma and the AH 130 Yoshida ascites hepatoma, microsomes are endowed with a greatly enhanced ODC-inactivating capacity, and, concurrently, ODC displays an extreme in vitro liability and an unusual thiol-dependency (most of the activity requires dithiothreitol supply to be determined). These data are at variance with those previously obtained in hepatomas induced by N-2-fluorenylacetamide (E. Gravela et al., (1983) Cancer Res., 42, 2298-2300). The possibility that ODC liability in the 2 hepatomas here studied may result from in vivo exposure to a strong microsomal activity is considered. |
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Authors:
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M F Zuretti; E Gravela |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer letters Volume: 36 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1987-07-23 Completed Date: 1987-07-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 35-43 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytosol / enzymology, metabolism Dithiothreitol / pharmacology Liver Neoplasms, Experimental / enzymology*, metabolism Male Microsomes, Liver / drug effects, enzymology*, metabolism Ornithine Decarboxylase / metabolism* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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3483-12-3/Dithiothreitol; EC 4.1.1.17/Ornithine Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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