Document Detail

Ornithine decarboxylase as a monitor for luteal stimuli in the pregnant rat.
MedLine Citation:
PMID:  6956733     Owner:  NLM     Status:  MEDLINE    
The sustained elevation during Days 12--21 of pregnancy of rat luteal ornithine decarboxylase, which is inducible experimentally by hCG and PGF-2 alpha, was dependent upon intact placentae and oestrogen, but independent of prostaglandin, and was absent at corresponding times of pseudopregnancy. It is suggested that his enzyme activity is a response to an hCG-like hormone of placental origin. Two brief reappearances of enzyme activity on Days 21 and 22 of pregnancy, dependent upon intact placentae and upon both oestrogen and prostaglandin, suggest a pulsatile release of PGF-2 alpha from the uterus or placentae. These experiments illustrate the value of ornithine decarboxylase in seeking unknown hormonal influences upon the corpus luteum.
D Hickman-Smith; L E Bussmann; N J Kuhn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  66     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  265-72     Citation Subset:  IM    
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MeSH Terms
Carboxy-Lyases / metabolism*
Chorionic Gonadotropin / pharmacology
Corpus Luteum / drug effects,  enzymology,  physiology*
Enzyme Induction / drug effects
Estrogens / physiology
Ornithine Decarboxylase / metabolism*
Placenta / physiology
Prostaglandins F / pharmacology
Rats, Inbred Strains
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Estrogens; 0/Prostaglandins F; 551-11-1/Dinoprost; EC 4.1.1.-/Carboxy-Lyases; EC Decarboxylase

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