Document Detail


Ornithine alpha-ketoglutarate and glutamine supplementation during refeeding of food-deprived rats.
MedLine Citation:
PMID:  1494205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to compare the efficiency of ornithine alpha-ketoglutarate (OKG) and glutamine supplementation in an experimental model of denutrition that provides well-characterized disturbances of amino acid patterns. Male Wistar rats (187 +/- 11 g; five in each group) were starved for 3 days and then refed for 7 days with an oral diet (192 kcal kg-1.day-1 and 2.25 g of nitrogen kg-1.day-1), supplemented with 0.19 g of nitrogen kg-1.day-1 in the form of OKG, glutamine, or casein (control group). Food deprivation induced a fall in most tissue amino acids, with the notable exception of muscle leucine and liver glutamate, which increased by 43% (p < .01), and 11% (p < .05), respectively. The main effect of OKG was seen in the viscera, with a normalization of most amino acid pools (including proline and branched-chain amino acids) in the small bowel and liver. The main effect of glutamine was observed in the muscle, with a normalization of the glutamine and leucine pools. We conclude that, in this model and with the doses used, OKG and glutamine act in different target tissues, ie, splanchnic areas and muscle, respectively.
Authors:
F Ziegler; C Coudray-Lucas; A Jardel; E Lasnier; J Le Boucher; O G Ekindjian; L Cynober
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  16     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    1992 Nov-Dec
Date Detail:
Created Date:  1993-03-09     Completed Date:  1993-03-09     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-10     Citation Subset:  IM    
Affiliation:
Laboratory of Biochemistry, Université Paris XI, Chatenay-Malabry, France.
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium
Amino Acids / metabolism
Animals
Disease Models, Animal
Food*
Glutamine / therapeutic use*
Male
Ornithine / analogs & derivatives*,  therapeutic use
Rats
Rats, Wistar
Starvation / diet therapy*,  metabolism
Chemical
Reg. No./Substance:
0/Amino Acids; 37339-58-5/ornithine alpha-ketoglutarate; 56-85-9/Glutamine; 7006-33-9/Ornithine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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