Document Detail


Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE.
MedLine Citation:
PMID:  23294494     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Astroglia, the most abundant cells in the human CNS, and even more prominent in multiple sclerosis patients, participate in CNS innate and adaptive immunity, and have been hypothesized to play an important role in multiple sclerosis progression. Experimental autoimmune encephalomyelitis elicited in mice by immunization with myelin oligodendrocyte glycoprotein peptide 35-55 provides a means by which to explore the genesis and disease significance of astrogliosis during a chronic immune-mediated CNS inflammatory/demyelinative disorder that, in its' pathological features, strongly resembles multiple sclerosis.
Authors:
Monica Moreno; Fuzheng Guo; Emily Mills Ko; Peter Bannerman; Athena Soulika; David Pleasure
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  -     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Institute for Pediatric Regenerative Research, UC Davis School of Medicine and Shriners Hospitals for Children Northern California, United States.
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