Document Detail

Origins of regulated cell-to-cell variability.
MedLine Citation:
PMID:  21224886     Owner:  NLM     Status:  In-Data-Review    
Single-cell measurements and lineage-tracing experiments are revealing that phenotypic cell-to-cell variability is often the result of deterministic processes, despite the existence of intrinsic noise in molecular networks. In most cases, this determinism represents largely uncharacterized molecular regulatory mechanisms, which places the study of cell-to-cell variability in the realm of molecular cell biology. Further research in the field will be important to advance quantitative cell biology because it will provide new insights into the mechanisms by which cells coordinate their intracellular activities in the spatiotemporal context of the multicellular environment.
Berend Snijder; Lucas Pelkmans
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Publication Detail:
Type:  Journal Article     Date:  2011-01-12
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  12     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  119-25     Citation Subset:  IM    
Swiss Federal Institute of Technology (ETH), Institute of Molecular Systems Biology, Wolfgang Pauli-Str. 16, CH-8093 Zürich, Switzerland.
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