Document Detail


Origins of the inhibiting effects of nasal CPAP on nonnutritive swallowing in newborn lambs.
MedLine Citation:
PMID:  18635879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study investigated the mechanism by which continuous positive airway pressure (CPAP) suppresses nonnutritive swallowing (NNS) during quiet sleep (QS) in newborn lambs. Eighteen full-term lambs were chronically instrumented and evenly distributed into three separate groups to determine the extent to which modulation of NNS may be attributed to stimulation of upper airway and/or bronchopulmonary mechanoreceptors. Six lambs were tracheotomized, six other lambs underwent a two-step bilateral intrathoracic vagotomy, and the remaining six lambs underwent chronic laryngotracheal separation (isolated upper airway group). Forty-eight hours after surgery, each nonsedated lamb underwent polysomnographic recordings on three consecutive days. States of alertness, NNS and respiratory movements were recorded. Results demonstrate that a CPAP of 6 cmH(2)O inhibited NNS during QS while administered directly on the lower airways and that bivagotomy prevented this inhibition. However, application of CPAP on the upper airways only also inhibited NNS during QS. Finally, the application of a CPAP of 6 cmH(2)O had no systematic effect on NNS-breathing coordination (assessed by the respiratory phase preceding and following NNS). In conclusion, our results suggest that bronchopulmonary receptors are implicated in the inhibiting effects of nasal CPAP of 6 cmH(2)O on NNS in all our experimental conditions, whereas upper airway receptors are only implicated in certain conditions.
Authors:
Nathalie Samson; Bianca Roy; Alain Ouimet; François Moreau-Bussière; Dominique Dorion; Sandeep Mayer; Jean-Paul Praud
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-17
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  105     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-07     Completed Date:  2008-11-06     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1083-90     Citation Subset:  IM    
Affiliation:
Departments of Pediatrics and Physiology, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Arousal
Continuous Positive Airway Pressure*
Deglutition*
Larynx / physiology*
Lung / innervation,  physiology*
Mechanotransduction, Cellular*
Polysomnography
Pulmonary Stretch Receptors / physiology*
Reflex
Respiratory Mechanics
Sheep
Sleep
Trachea / innervation,  physiology*
Tracheotomy
Vagotomy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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