Document Detail


Origins and formation of histone methylation across the human cell cycle.
MedLine Citation:
PMID:  22547680     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The connections between various nuclear processes and specific histone posttranslational modifications are dependent to a large extent on the acquisition of those modifications after histone synthesis. The reestablishment of histone posttranslational modifications after S phase is especially critical for H3K9 and H3K27 trimethylation, both of which are linked with epigenetic memory and must be stably transmitted from one cellular generation to the next. This report uses a proteomic strategy to interrogate how and when the cell coordinates the formation of histone posttranslational modifications during division. Paramount among the findings is that H3K9 and H3K27 trimethylation begins during S phase but is completed only during the subsequent G(1) phase via two distinct pathways from the unmodified and preexisting dimethylated states. In short, we have systematically characterized the temporal origins and methylation pathways for histone posttranslational modifications during the cell cycle.
Authors:
Barry M Zee; Laura-Mae P Britton; Daniel Wolle; Devorah M Haberman; Benjamin A Garcia
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-04-30
Journal Detail:
Title:  Molecular and cellular biology     Volume:  32     ISSN:  1098-5549     ISO Abbreviation:  Mol. Cell. Biol.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-09-06     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8109087     Medline TA:  Mol Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2503-14     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Base Sequence
Binding Sites
Cell Cycle / genetics,  physiology*
DNA Primers / genetics
Epigenesis, Genetic
G1 Phase / genetics,  physiology
HeLa Cells
Histones / chemistry,  genetics,  metabolism*
Humans
Methionine / chemistry
Methylation
Models, Biological
Molecular Sequence Data
Protein Processing, Post-Translational
S Phase / genetics,  physiology
Signal Transduction
Grant Support
ID/Acronym/Agency:
DP2 OD007447/OD/NIH HHS; DP2OD007447/OD/NIH HHS
Chemical
Reg. No./Substance:
0/DNA Primers; 0/Histones; 63-68-3/Methionine
Comments/Corrections

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