| Origins and formation of histone methylation across the human cell cycle. | |
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MedLine Citation:
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PMID: 22547680 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The connections between various nuclear processes and specific histone posttranslational modifications are dependent to a large extent on the acquisition of those modifications after histone synthesis. The reestablishment of histone posttranslational modifications after S phase is especially critical for H3K9 and H3K27 trimethylation, both of which are linked with epigenetic memory and must be stably transmitted from one cellular generation to the next. This report uses a proteomic strategy to interrogate how and when the cell coordinates the formation of histone posttranslational modifications during division. Paramount among the findings is that H3K9 and H3K27 trimethylation begins during S phase but is completed only during the subsequent G(1) phase via two distinct pathways from the unmodified and preexisting dimethylated states. In short, we have systematically characterized the temporal origins and methylation pathways for histone posttranslational modifications during the cell cycle. |
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Authors:
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Barry M Zee; Laura-Mae P Britton; Daniel Wolle; Devorah M Haberman; Benjamin A Garcia |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-04-30 |
Journal Detail:
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Title: Molecular and cellular biology Volume: 32 ISSN: 1098-5549 ISO Abbreviation: Mol. Cell. Biol. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-11 Completed Date: 2012-09-06 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 8109087 Medline TA: Mol Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 2503-14 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Base Sequence Binding Sites Cell Cycle / genetics, physiology* DNA Primers / genetics Epigenesis, Genetic G1 Phase / genetics, physiology HeLa Cells Histones / chemistry, genetics, metabolism* Humans Methionine / chemistry Methylation Models, Biological Molecular Sequence Data Protein Processing, Post-Translational S Phase / genetics, physiology Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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DP2OD007447/OD/NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Histones; 63-68-3/Methionine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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