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Original β,γ-diamino acid as an inducer of a γ-turn mimic in short peptides.
MedLine Citation:
PMID:  23143084     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Original αγα tripeptides containing one β,γ-diamino acid have been synthesized and their conformation determined by extensive NMR and molecular dynamic studies. These studies revealed the presence of a C(9) hydrogen bonded turn around the β,γ-diamino acid which was stabilized by bulky side chains of the preceding residue. This turn can be considered as a mimic of the well-known γ-turn.
Authors:
Sophie Thétiot-Laurent; Francelin Bouillère; Jean-Pierre Baltaze; François Brisset; Debby Feytens; Cyrille Kouklovsky; Emeric Miclet; Valérie Alezra
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-12
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  -     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratoire de Chimie des Procédés et Substances Naturelles, ICMMO, UMR 8182, Univ Paris-Sud, CNRS, Bât 410, Orsay F-91405, France. valerie.alezra@u-psud.fr.
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