Document Detail


Stearic acid delivery to corneum from a mild and moisturizing cleanser.
MedLine Citation:
PMID:  20883293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: A mild moisturizing body wash with stearic acid, a key component of corneum lipids, and emollient soybean oil has been introduced in the market place. The objectives of this study are to determine the amount and the location of the stearic acid in the corneum after in vivo cleansing by the formulation.
METHOD: Clinical cleansing studies for one and five consecutive days were carried out with the formulation containing soybean oil or petroleum jelly (PJ). The free stearic acid in it was replaced by the fully deuterated variant. The amounts of stearic acid in 10 consecutive corneum tape strips were measured by liquid chromatograph-mass spectroscopy. Separately, electron paramagnetic resonance (EPR) measurements were taken with a porcine skin after a wash by the soybean oil formulation with its free fatty acid replaced by its spin probe analogue, 5-doxyl stearic acid.
RESULTS: Deuterated stearic acid was detected in all 10 consecutive layers of stratum corneum and the total amount after five washes with the soybean oil formulation was 0.33 μg/cm². The spin probe in cleanser-treated skin was incorporated in a partially ordered hydrophobic region similar to corneum lipids. The probe mobility increased in the temperature region where lipid disorder was expected.
CONCLUSIONS: The estimated total fatty acid delivered to skin from cleansing is comparable to the amount of fatty acid in a corneum layer. The delivered fatty acid is most likely incorporated in the corneum lipid phase.
Authors:
Surajit Mukherjee; Melody Edmunds; Xuegong Lei; Maria Francesca Ottaviani; Kavssery P Ananthapadmanabhan; Nicholas J Turro
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cosmetic dermatology     Volume:  9     ISSN:  1473-2165     ISO Abbreviation:  J Cosmet Dermatol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130964     Medline TA:  J Cosmet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  202-10     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley Periodicals, Inc.
Affiliation:
Unilever HPC-NA, Trumbull, CT, USA. surajit.mukherjee@unilever.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Baths
Cyclic N-Oxides / pharmacology
Detergents / administration & dosage,  therapeutic use*
Drug Delivery Systems
Electron Spin Resonance Spectroscopy / methods
Female
Single-Blind Method
Skin Physiological Phenomena* / drug effects
Spin Labels
Stearic Acids / administration & dosage,  therapeutic use*
Swine
Chemical
Reg. No./Substance:
0/Cyclic N-Oxides; 0/Detergents; 0/Spin Labels; 0/Stearic Acids; 29545-48-0/5-doxylstearic acid; 57-11-4/stearic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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