Document Detail


Origin of some derivatives of retinoic acid found in rat bile.
MedLine Citation:
PMID:  5726316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
After the intraportal injection of retinoic acid-15-(14)C into rats, all-trans methyl retinoate, a cis isomer of methyl retinoate, retinoyl beta-glucurono-gamma-lactone, retinoic acid, and retinoyl beta-glucuronide were isolated from methanol extracts of rat bile by chromatography on anion-exchange resin and silicic acid columns and characterized on thin-layer plates of Silica Gel G. On the other hand, when bile was extracted with n-butanol or analyzed directly by thin-layer chromatography, only retinoyl beta-glucuronide and a very small amount of retinoic acid could be detected. Butanol extracts of the liver and the intestine, however, still contained a small radioactive nonpolar fraction. When retinoyl beta-glucuronide was incubated with an anion-exchange resin in the presence of methanol, several nonpolar products appeared. Apparently the methyl retinoate, retinoyl beta-glucurono-gamma-lactone, and most of the retinoic acid previously found in bile after retinoic acid administration are produced from retinoyl beta-glucuronide during the isolation procedure.
Authors:
K Lippel; J A Olson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of lipid research     Volume:  9     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1968 Sep 
Date Detail:
Created Date:  1969-02-04     Completed Date:  1969-02-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  580-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acids / metabolism
Animals
Bile*
Bile Ducts / physiology
Carbon Isotopes
Chemical Phenomena
Chemistry
Chromatography, Ion Exchange
Chromatography, Thin Layer
Crystallization
Esters
Glucuronates / metabolism
Glucuronidase
Lactones / metabolism
Male
Rats
Stereoisomerism
Vitamin A / metabolism*
Chemical
Reg. No./Substance:
0/Acids; 0/Carbon Isotopes; 0/Esters; 0/Glucuronates; 0/Lactones; 11103-57-4/Vitamin A; EC 3.2.1.31/Glucuronidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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