Document Detail


Origin of segmental identity in the development of the leech nervous system.
MedLine Citation:
PMID:  1688179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The leech embryo develops its segmental body plan by means of a stereotyped cell lineage. Each hemilateral segment arises from a small set of embryonic blast cells via a comparable sequence of formative cell divisions, and for the most part, lineally homologous cells manifest similar patterns of differentiation in the various hemisegments. Nonetheless, some identified central neurons undergo segment-specific or laterally asymmetric patterns of neuropeptide expression and/or cell death. Certain aspects of this regional diversification result from competitive cell interactions which occur at the level of the postmitotic neuron. However, the neuron's segmental identity is lineally determined, being inherited from its blast cell progenitor over several intervening rounds of mitosis. To learn more about the molecular basis of this phenomenon, we have isolated and begun to characterize leech homeobox genes which are related to the genes that govern segmental identity in other organisms.
Authors:
M Shankland; M Q Martindale; D Nardelli-Haefliger; E Baxter; D J Price
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  Suppl 2     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1991  
Date Detail:
Created Date:  1993-01-04     Completed Date:  1993-01-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  29-38     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Drosophila / genetics
Embryonic Induction / physiology*
Genes, Homeobox / genetics
Leeches / embryology*,  genetics
Molecular Sequence Data
Nervous System / embryology*
Neurons / cytology*
Sequence Homology, Amino Acid
Stem Cells / cytology*
Grant Support
ID/Acronym/Agency:
F32-GM12481/GM/NIGMS NIH HHS; R01-HD21735/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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