Document Detail

Origin of prostanoids in human amniotic fluid: the fetal kidney as a source of amniotic fluid prostanoids.
MedLine Citation:
PMID:  6638096     Owner:  NLM     Status:  MEDLINE    
The present study was designed to investigate the origin of prostanoids that are present in amniotic fluid. We evaluated the concentration of prostaglandins in fetal urine that was obtained from newborn infants immediately after delivery either before or after the onset of spontaneous labor or after oxytocin-induced labor. We found that the levels of prostaglandin (PG) E2, PGF2 alpha, 6-keto-PGF1 alpha, and 13, 14-dihydro-15-keto-PGF2 alpha in the fetal urine of newborn infants delivered after the spontaneous onset of labor and after oxytocin-induced labor were significantly greater than the levels in the fetal urine of newborn infants delivered before the spontaneous onset of labor. We conclude that one source of the prostanoids present in amniotic fluid is fetal urine, and, thence, fetal kidneys, and that labor, whether spontaneous or induced, caused increased excretion of prostanoids in fetal urine.
M L Casey; S I Cutrer; M D Mitchell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  147     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  AIM; IM    
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MeSH Terms
Amniotic Fluid / analysis*
Cesarean Section
Fetus / physiology*
Infant, Newborn
Kidney / secretion*
Labor, Induced
Labor, Obstetric
Oxytocin / pharmacology
Prostaglandins / secretion*,  urine
Time Factors
Grant Support
Reg. No./Substance:
0/Prostaglandins; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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