Document Detail

Origin and outcome of multiple pregnancies in Bern, Switzerland, 1995-2006 and the current proposal of the Swiss parliament to revise the Swiss law of reproductive medicine: Switzerland quo vadis?
MedLine Citation:
PMID:  24089329     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Infertility treatments are a major source of the increase in multiple pregnancies (MPs).
AIMS: The aims of the present study were (1.) to investigate the origin and maternal/neonatal outcomes of MP and (2.) to review the different measures that can be adopted to reduce these serious complications.
METHODS: The study included all women with multiple births between 1 January 1995 and 31 December 2006 at the University Hospital of Bern, Switzerland. The outcomes associated with the various origins of MP (natural conception, ovarian stimulation [OS] ‒ in-vitro fertilisation [IVF-ICSI]) were analysed using a multinomial logistic regression model. An analysis of the Swiss law on reproductive medicine and its current proposed revision, as well as a literature review using Pubmed, was carried out.
RESULTS: A total of 592 MP were registered, 91% (n = 537) resulted in live births. There was significantly more neonatal/maternal morbidity in MP after OS compared with natural conception and even with the IVF-ICSI group. With a policy of elective single embryo transfer (eSET), twin rates after IVF-ICSI can be reduced to <5% and triplets to <1%.
CONCLUSIONS: After OS, more triplets are found and the outcome of MP is worse. MP is known to be associated with morbidity, mortality, and economic and social risks. To counteract these complications (1.) better training for physicians performing OS should be encouraged and (2.) the Swiss law on reproductive medicine needs to be changed, with the introduction of eSET policies. This would lead to a dramatic decrease in neonatal and maternal morbidity/mortality as well as significant cost reductions for the Swiss healthcare system.
D Wunder; E M Neurohr; M Faouzi; M H Birkhäuser
Related Documents :
18346279 - Real-time pcr/mca assay using fluorescence resonance energy transfer for the genotyping...
24485199 - Fetal demise and associated factors following umbilical cord prolapse in mulago hospita...
23112019 - Carpal tunnel syndrome in pregnancy - you need to ask!
23444769 - Pheochromocytoma in ectopic pregnancy: a case report.
24761129 - Hysteroscopic removal of cervical ectopic pregnancy following failed intramuscular/intr...
24839149 - Counseling for fetal macrosomia: an estimated fetal weight of 4,000 g is excessively lo...
4050289 - A study of the influence of ovulation stimulants and oral contraception on twin births ...
23738229 - Management of thyroid peroxidase antibody euthyroid women in pregnancy: comparison of t...
9710039 - Pregnancy outcome following first trimester exposure to sumatriptan.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-19
Journal Detail:
Title:  Swiss medical weekly     Volume:  143     ISSN:  1424-3997     ISO Abbreviation:  Swiss Med Wkly     Publication Date:  2013  
Date Detail:
Created Date:  2013-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100970884     Medline TA:  Swiss Med Wkly     Country:  -    
Other Details:
Languages:  ENG     Pagination:  w13864     Citation Subset:  -    
Unité de Médecine de Reproduction, Lausanne, SWITZERLAND;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A Mendelian predisposition to B cell lymphoma caused by IL-10R deficiency.
Next Document:  An ITS-based phylogenetic framework for the genus Vorticella: finding the molecular and morphologica...