Document Detail


Origin of informational polymers: The concurrent roles of formamide and phosphates.
MedLine Citation:
PMID:  17051657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Formamide chemistry provides a unitary system by gathering all of the precursors needed to synthesise pregenetic informational polymers in a single milieu. This is not observed with HCN chemistry. With common catalysts, formamide affords all of the precursor nucleobases, photochemically condenses into acyclonucleosides, favours transphosphorylation and enhances micellar aggregation of surfactants. Also, formamide provides a set of physicochemical conditions that thermodynamically favour the polymeric state of nucleotides over the monomers. In the origin-of-informational-polymers scenario, formamide acts in every step, the least characterised being the set of its reactions with phosphates. On this matter, we report two complementary sets of results: 1) the synthesis of prebiotic precursors from formamide, which are catalysed by soluble and mineral phosphates-we observed the formation of rich mixtures that include uracil, 9H-purine, cytosine, dihydrouracil, hypoxanthine, adenosine, urea, parabanic acid, the amino acid N-formylglycine and the peptide-condensing agent carbodiimide; and 2) the protection of ribo- and deoxyribophosphoester bonds by phosphates. The relevance of these effects with respect to the origin of informational polymers is discussed.
Authors:
Raffaele Saladino; Claudia Crestini; Veronica Neri; Fabiana Ciciriello; Giovanna Costanzo; Ernesto Di Mauro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chembiochem : a European journal of chemical biology     Volume:  7     ISSN:  1439-4227     ISO Abbreviation:  Chembiochem     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2007-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100937360     Medline TA:  Chembiochem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1707-14     Citation Subset:  IM    
Affiliation:
Dipartimento A.B.A.C., Università della Tuscia, Via San Camillo De Lellis, 01100 Viterbo, Italy. saladino@unitus.it
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MeSH Terms
Descriptor/Qualifier:
Catalysis
DNA / genetics
Formamides / chemistry*
Minerals / chemistry
Molecular Structure
Phosphates / chemistry*
Polymers / chemistry*
RNA / genetics
Solubility
Chemical
Reg. No./Substance:
0/Formamides; 0/Minerals; 0/Phosphates; 0/Polymers; 12190-77-1/pyromorphite; 63231-63-0/RNA; 75-12-7/formamide; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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