Document Detail

Origin of hydrocortisone induced orofacial clefts in the chick embryo.
MedLine Citation:
PMID:  6572574     Owner:  NLM     Status:  MEDLINE    
The growth and fusion of facial processes were studied in White Leghorn chicken embryos treated with hydrocortisone. This treatment results in complete bilateral cleft beak in 80-100% of cases. The frontonasal complex of the experimental embryos exhibited marked hypoplasia prior to cleft manifestation. During the critical period for cleft beak formation, the maximum mitotic activity was concentrated in the medial nasal processes, which thus became vulnerable to the mitosis inhibiting effect of corticoids. Primary hypoplasia of the facial processes was documented as a causative factor of corticoid-induced cleft beak which is analogous to mammalian cleft lip/palate.
M Peterka; R Jelinek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Cleft palate journal     Volume:  20     ISSN:  0009-8701     ISO Abbreviation:  Cleft Palate J     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372737     Medline TA:  Cleft Palate J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-46     Citation Subset:  D; IM    
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MeSH Terms
Chick Embryo
Face / abnormalities*,  embryology
Hydrocortisone / adverse effects*
Maxilla / embryology
Mesoderm / drug effects,  physiology
Mouth / embryology
Mouth Abnormalities / chemically induced*
Nose / embryology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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