Document Detail


Origin of human chromosome 2: an ancestral telomere-telomere fusion.
MedLine Citation:
PMID:  1924367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have identified two allelic genomic cosmids from human chromosome 2, c8.1 and c29B, each containing two inverted arrays of the vertebrate telomeric repeat in a head-to-head arrangement, 5'(TTAGGG)n-(CCCTAA)m3'. Sequences flanking this telomeric repeat are characteristic of present-day human pretelomeres. BAL-31 nuclease experiments with yeast artificial chromosome clones of human telomeres and fluorescence in situ hybridization reveal that sequences flanking these inverted repeats hybridize both to band 2q13 and to different, but overlapping, subsets of human chromosome ends. We conclude that the locus cloned in cosmids c8.1 and c29B is the relic of an ancient telomere-telomere fusion and marks the point at which two ancestral ape chromosomes fused to give rise to human chromosome 2.
Authors:
J W IJdo; A Baldini; D C Ward; S T Reeders; R A Wells
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  88     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-11-15     Completed Date:  1991-11-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9051-5     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M73018;  S60062;  S60067;  S60069;  S60071;  S60073;  S60076;  S60079;  S60081;  X59397
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Cells, Cultured
Chromosome Mapping
Chromosomes, Human, Pair 2*
Cloning, Molecular
Cosmids
DNA / genetics
DNA Probes
Evolution*
Genomic Library
Humans
Karyotyping
Lymphocytes / cytology,  physiology
Metaphase
Microscopy, Fluorescence
Molecular Sequence Data
Nucleic Acid Hybridization
Repetitive Sequences, Nucleic Acid
Telomere / physiology*
Chemical
Reg. No./Substance:
0/DNA Probes; 9007-49-2/DNA
Comments/Corrections

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