Document Detail

Origin of hepatic triglyceride fatty acids: quantitative estimation of the relative contributions of linoleic acid by diet and adipose tissue in normal and ethanol-fed rats.
MedLine Citation:
PMID:  5016299     Owner:  NLM     Status:  MEDLINE    
The present study demonstrates that the rat liver obtains most of its triglyceride fatty acids from dietary sources. The dietary and adipose tissue contributions of linoleic acid for hepatic triglyceride esterification were shown to be 50.42 and 13.85 micro moles, respectively, during a 4-day period. When ethanol provided 40% of the caloric intake, fatty liver developed and hepatic triglyceride content increased threefold. Under these conditions, the dietary and adipose tissue contributions of linoleic acid were estimated at 192.85 and 10.73 micro moles, respectively. This increase in dietary fatty acid utilization was sufficient to account for the entire increase in esterified hepatic linoleic acid. Any explanation of these observations must include the high dietary fatty acid utilization in both control and ethanol-treated animals. One possibility is that most dietary lipids first enter a rapidly turning over pool in adipose tissue from which most hepatic triglyceride fatty acids are derived. Another is that dietary fatty acids, incorporated into chylomicrons, are stored separately and used preferentially by the liver as compared with lipids derived from adipose tissue and bound to albumin. The pros and cons of these possibilities are discussed.
C L Mendenhall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of lipid research     Volume:  13     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1972 Mar 
Date Detail:
Created Date:  1972-06-13     Completed Date:  1972-06-13     Revised Date:  2007-03-20    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / metabolism*
Chromatography, Thin Layer
Chylomicrons / metabolism
Dietary Fats
Ethanol / pharmacology
Fatty Acids / biosynthesis*,  metabolism
Fatty Acids, Essential / biosynthesis
Fatty Liver / chemically induced,  metabolism
Glycerol / metabolism
Linoleic Acids / metabolism*
Liver / drug effects,  metabolism*
Triglycerides / biosynthesis*
Reg. No./Substance:
0/Chylomicrons; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Essential; 0/Linoleic Acids; 0/Triglycerides; 10028-17-8/Tritium; 56-81-5/Glycerol; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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