| Origin and diversification of the L-amino oxidase family in innate immune defenses of animals. | |
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MedLine Citation:
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PMID: 20878154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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L-amino acid oxidases (LAOs), because they produce hydrogen peroxide as a by-product, function in innate immune defenses of both vertebrates and mollusks. Phylogenetic analysis revealed two major subfamilies of LAOs: (1) a subfamily including LAOs from vertebrates and mainly from Terrabacteria and (2) a subfamily including LAOs from mollusks and Hydrobacteria. These subfamilies thus originated early in the history of life, implying that their innate immune functions in vertebrates and mollusks have evolved separately. Mammalian LAOs were found to belong to three separate clades: (1) LAO1, (2) LAO2, and (3) IL4I1. Phylogenetic analysis supported the hypothesis that LAO1 and LAO2 arose by a gene duplication prior to the divergence of marsupials from placental mammals, while IL4I1 duplicated from the ancestor of the LAO1 and LAO2 prior to the divergence of tetrapods from bony fishes. Mammalian IL4I1 clustered with LAOs from bony fishes, and these molecules shared a number of unique sequence features, including both amino acid replacements and a unique two-codon deletion. It is certain such unique features may be functionally important, especially three unique amino acid replacements in close proximity to the putative active site. |
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Authors:
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Austin L Hughes |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-28 |
Journal Detail:
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Title: Immunogenetics Volume: 62 ISSN: 1432-1211 ISO Abbreviation: Immunogenetics Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-11 Completed Date: 2010-11-26 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0420404 Medline TA: Immunogenetics Country: United States |
Other Details:
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Languages: eng Pagination: 753-9 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC 29208, USA. austin@biol.sc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Bacteria / enzymology Evolution, Molecular* Humans Immunity, Innate* L-Amino Acid Oxidase / chemistry, genetics* Molecular Sequence Data Phylogeny Sequence Alignment |
| Grant Support | |
ID/Acronym/Agency:
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GM43940/GM/NIGMS NIH HHS; R01 GM043940-21/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 1.4.3.2/L-Amino Acid Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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