Document Detail


Orientation-selective functional magnetic resonance imaging adaptation in primary visual cortex revisited.
MedLine Citation:
PMID:  21425395     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The processing of orientations is at the core of our visual experience. Orientation selectivity in human visual cortex has been inferred from psychophysical experiments and more recently demonstrated with functional magnetic resonance imaging (fMRI). One method to identify orientation-selective responses is fMRI adaptation, in which two stimuli-either with the same or with different orientations-are presented successively. A region containing orientation-selective neurons should demonstrate an adapted response to the "same orientation" condition in contrast to the "different orientation" condition. So far, human primary visual cortex (V1) showed orientation-selective fMRI adaptation only in experimental designs using prolonged pre-adaptation periods (∼40 s) in combination with top-up stimuli that are thought to maintain the adapted level. This finding has led to the notion that orientation-selective short-term adaptation in V1 (but not V2 or V3) cannot be demonstrated using fMRI. The present study aimed at re-evaluating this question by testing three differently timed adaptation designs. With the use of a more sensitive analysis technique, we show robust orientation-selective fMRI adaptation in V1 evoked by a short-term adaptation design. Hum Brain Mapp, 2011. © 2011 Wiley-Liss, Inc.
Authors:
Sarah Weigelt; Katharina Limbach; Wolf Singer; Axel Kohler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-21
Journal Detail:
Title:  Human brain mapping     Volume:  -     ISSN:  1097-0193     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9419065     Medline TA:  Hum Brain Mapp     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Department of Neurophysiology, Max Planck Institute for Brain Research, Deutschordenstr 46, 60528 Frankfurt am Main, Germany; Brain Imaging Center Frankfurt, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany; Department of Brain and Cognitive Sciences and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139. weigelt@mit.edu.
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