Document Detail

Orientation entropy analysis of diffusion tensor in healthy and myelopathic spinal cord.
MedLine Citation:
PMID:  21777679     Owner:  NLM     Status:  Publisher    
The majority of nerve fibers in the spinal cord run longitudinally, playing an important role in connecting the brain to the peripheral nerves. There is a growing interest in applying diffusion tensor imaging (DTI) to the evaluation of spinal cord microarchitecture. The current study sought to compare the organization of longitudinal nerve fibers between healthy and myelopathic spinal cords using entropy-based analysis of principal eigenvector mapping. A total of 22 subjects were recruited, including 14 healthy subjects, seven cervical myelopathy (CM) patients with single-level compression, and one patient suffering from multi-level compression. Diffusion tensor magnetic resonance (MR) images of the cervical spinal cord were obtained using a pulsed gradient, spin-echo echo-planar imaging (SE-EPI) sequence with a 3T MR system. Regions of interest (ROIs) were drawn manually to cover the spinal cord, and Shannon entropy was calculated in principal eigenvector maps. The results revealed no significant differences in orientation entropy values along the whole length of cervical spinal cord in healthy subjects (C2-3: 0.73±0.05; C3-4: 0.71±0.07; C4-5: 0.72±0.048; C5-6: 0.71±0.07; C6-7: 0.72±0.07). In contrast, orientation entropy values in myelopathic cord were significantly higher at the compression site (0.91±0.03), and the adjacent levels (above: 0.85±0.03; below: 0.83±0.05). This study provides a novel approach to analyze the orientation information in diffusion MR images of healthy and diseased spinal cord. These results indicate that orientation entropy can be applied to determine the contribution of each compression level to the overall disorganization of principal nerve tracts of myelopathic spinal cord in cases with multi-level compression.
Jiao-Long Cui; Chun-Yi Wen; Yong Hu; Kin-Cheung Mak; Ka-Hung Henry Mak; Keith Dip-Kei Luk
Related Documents :
12859059 - Computerized tomography-guided percutaneous transforaminodiscal biopsy sampling of vert...
1606759 - General principles in the diagnosis and treatment of vulvar diseases.
22848019 - Gd-eob-dtpa-enhanced mr imaging: prediction of hepatic fibrosis stages using liver cont...
20431769 - Idiopathic isolated omental panniculitis confirmed by percutaneous ct-guided biopsy.
12216759 - Design of quality assurance for sonographic prostate brachytherapy needle guides.
9839139 - Negative images due to mai infection detected in papanicolaou-stained duodenal brushing...
21359519 - Mr fluoroscopy in vascular and cardiac interventions (review).
10524749 - The significance of incidental noncardiac findings in tc-99m sestamibi myocardial perfu...
10914629 - Prenatal magnetic resonance imaging assisting in differentiating between large degenera...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-18
Journal Detail:
Title:  NeuroImage     Volume:  -     ISSN:  1095-9572     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Strategies for bacterial expression of protein-peptide complexes: application to solubilization of p...
Next Document:  MRI atlas of the human hypothalamus.