Document Detail


Oridonin ameliorates lupus-like symptoms of MRL(lpr/lpr) mice by inhibition of B-cell activating factor (BAFF).
MedLine Citation:
PMID:  23712004     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Oridonin, a pharmacologically safe agent extracted from Isodon Serra, has been shown to possess potent anti-inflammatory properties. However, it is not clear whether Oridonin affects B-cell activating factor (BAFF) expression, thereby exerting beneficial effects in the treatment of BAFF-associated autoimmune diseases such as systemic lupus erythematosus (SLE). Thus, the current study aimed to find the function of Oridonin in regulation of BAFF and amelioration of SLE. In vitro, we explored the effect of Oridonin on BAFF expression and production in mouse macrophages. Moreover, using a spontaneous murine SLE model, we investigated the role of Oridonin delivery in the treatment of lupus-like disease in MRL(lpr/lpr) mice, by measuring the changes in lupus symptoms, renal damage, BAFF expression, and B cell subsets. Our results showed that Oridonin significantly inhibited BAFF expression in mouse macrophages by suppressing the transcriptional activation of its promoter. And in vivo administration of Oridonin efficiently ameliorated the serological and clinical manifestations of SLE in MRL(lpr/lpr) mice, as shown by increased survival benefit, reduced proteinuria levels, diminished production of specific auto-antibodies, and attenuated renal damage, in association with down-regulation of BAFF and a lower rate of B-cell maturation and differentiation. Thus, it suggests that Oridonin will serve as a novel natural therapeutic strategy for SLE by inhibition of BAFF.
Authors:
Lin Zhou; Lijuan Sun; Hongkun Wu; Lingzhen Zhang; Mingcang Chen; Jianwen Liu; Renqian Zhong
Related Documents :
8857284 - Antinucleolar autoantibody induced by mercuric chloride in mice: does sodium selenite i...
25078604 - Regulation of feto-maternal barrier by matriptase- and par-2-mediated signaling is requ...
12373454 - Role of metabolites in mdma (ecstasy)-induced nephrotoxicity: an in vitro study using r...
25016204 - Induction of protection against foot-and-mouth disease virus in cell culture and transg...
9358744 - Mice lacking the thrombin receptor, par1, have normal skin wound healing.
2308394 - Phenotypic and functional properties of b lymphocytes from aged mice.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-24
Journal Detail:
Title:  European journal of pharmacology     Volume:  -     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.
Affiliation:
Department of Laboratory Medicine, Changzhen Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. Electronic address: gracelin_zhou@yahoo.com.cn.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hypoxia: A Master Regulator of MicroRNA Biogenesis and Activity: Hypoxic Regulation of MicroRNAs.
Next Document:  Centhaquin antinociception in mice is mediated by ?2A and ?2B but not ?2C adrenoceptors.