Document Detail


Organosulfur compounds from garlic (Allium sativum) oxidizing canine erythrocytes.
MedLine Citation:
PMID:  12872937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sulfurous acid ester, trans-sulfurous acid allyl ester 3-allylsulfanyl-allyl ester 8, along with two known thiosulfinates was isolated from the aqueous ethanol extract of garlic (Allium sativum). The chemical structure of 8 was determined on the basis of spectroscopic data including high resolution mass and two-dimensional NMR techniques. All of these compounds induced methemoglobin formation in a canine erythrocyte suspension in vitro resulting in the oxidation of canine erythrocytes. This is the first report of sulfurous acid ester showing oxidant activity in canine erythrocytes.
Authors:
Qing Yang; Qiuhui Hu; Osamu Yamato; Keun-Woo Lee; Yoshimitsu Maede; Teruhiko Yoshihara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zeitschrift für Naturforschung. C, Journal of biosciences     Volume:  58     ISSN:  0939-5075     ISO Abbreviation:  Z. Naturforsch., C, J. Biosci.     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-07-22     Completed Date:  2003-10-21     Revised Date:  2009-11-04    
Medline Journal Info:
Nlm Unique ID:  8912155     Medline TA:  Z Naturforsch C     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  408-12     Citation Subset:  IM    
Affiliation:
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, 060-8589, Japan.
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MeSH Terms
Descriptor/Qualifier:
Alkanesulfonates / chemistry*,  isolation & purification,  pharmacology
Animals
Biological Assay
Dogs
Erythrocytes / drug effects*
Ethanol
Garlic*
Magnetic Resonance Spectroscopy
Oxidation-Reduction
Plant Extracts / chemistry
Sulfinic Acids / chemistry*,  isolation & purification,  pharmacology
Chemical
Reg. No./Substance:
0/Alkanesulfonates; 0/Plant Extracts; 0/Sulfinic Acids; 0/sulfurous acid allyl ester 3-allylsulfanylallyl ester; 0/thiosulfinic acids; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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