Document Detail

Organogenesis: molecular mechanisms of tubulogenesis.
MedLine Citation:
PMID:  12094229     Owner:  NLM     Status:  MEDLINE    
As organisms have evolved in size and complexity, tubular systems have developed to enable the efficient transport of substances into and out of tissues. These tubular systems are generated using strategies that are based on common elements of cell behaviour, including cell polarization, tube migration to target sites, cell-fate diversification and localization of specialized cells to different regions of the tube system. Using examples from both invertebrate and vertebrate systems, this review highlights progress in understanding these basic principles and briefly discusses the possible evolution of strategies to regulate the morphogenesis of tubular systems.
Brigid L M Hogan; Peter A Kolodziej
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Nature reviews. Genetics     Volume:  3     ISSN:  1471-0056     ISO Abbreviation:  Nat. Rev. Genet.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-02     Completed Date:  2002-07-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100962779     Medline TA:  Nat Rev Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  513-23     Citation Subset:  IM    
Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt Medical Center, Nashville, Tennessee 37232-2175, USA.
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MeSH Terms
Cell Physiological Phenomena
Cell Polarity
Embryonic and Fetal Development / physiology*
Neovascularization, Physiologic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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