Document Detail


Organochlorine contaminants in human adipose tissues from China: mass balance approach for estimating historical Chinese exposure to DDTs.
MedLine Citation:
PMID:  16053068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concentrations of persistent organochlorines (OCs), such as DDTs, hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), polychlorinated biphenyls (PCBs), and chlordane compounds (CHLs) were determined in 34 human adipose tissues collected from Guizhou Province, southern China, during 2002. DDT was the predominant contaminant among OCs analyzed; concentrations ranged from 420 to 20 000 ng/g on a lipid wt basis (average +/- sd: 5700 +/- 4100 ng/g). Concentrations of DDTs and the ratio of p,p'-DDT/ sigmaDDT in humans in China were significantly higher than those reported for developed countries. DDT levels in humans in Guizhou Province were comparable to those from Shanghai City, implying the presence of significant sources of DDTs in inland and coastal areas in China. Age-dependent accumulation of HCH concentration was found in this study, possibly because of the considerable reduction in average dairy intake (ADI) of HCHs by Chinese during the recent two decades. On the basis of the information of the ADI rates, half-lives, and body burdens of DDTs, the magnitude of historical DDT exposures by Chinese was estimated. This suggested that approximately 80% of DDTs deposited in Chinese adipose tissues was accumulated before the 1990s. The monitoring of OC levels and epidemiological studies are needed in China to understand the status of contamination and the risks to humans.
Authors:
Haruhiko Nakata; Tetsuya Nasu; Shin-Ichi Abe; Takeshi Kitano; Qiyuan Fan; Weihua Li; Xucheng Ding
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Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  Environmental science & technology     Volume:  39     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-08-01     Completed Date:  2005-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4714-20     Citation Subset:  IM    
Affiliation:
Graduate School of Science and Technology, Kumamoto University 2-39-1 Kurokami, Kumamoto 860-8555 Japan. nakata@sci.kumamoto-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / chemistry
Adolescent
Adult
Age Factors
Aged
China
DDT / analysis,  history,  pharmacokinetics*
Environmental Exposure*
Epidemiologic Studies
Female
History, 20th Century
Humans
Hydrocarbons, Chlorinated / analysis,  history,  pharmacokinetics*
Insecticides / analysis,  history,  pharmacokinetics*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Hydrocarbons, Chlorinated; 0/Insecticides; 50-29-3/DDT

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