Document Detail

Organochlorine compounds in breast-fed vs. bottle-fed infants: preliminary results at six weeks of age.
MedLine Citation:
PMID:  15262173     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) are ubiquitous compounds with carcinogenic and teratogenic properties. They are chemically very stable and lipophilic and, therefore, accumulate in our food-chain. They are prenatally transmitted from mother to foetus, and mother's milk due to its high lipid content is an elimination pathway of special importance. Therefore, breast-feeding has been held responsible for elevated concentrations of these organochlorine compounds as well as for harmful effects in children later in life. METHODS: Blood samples (2.5 ml) were taken from each 10 breast-fed and bottle-fed infants at 6 weeks of age. Blood specimens were immediately centrifuged, and serum was stored in glass tubes at -20 degrees C until analysis. Three higher chlorinated PCB congeners (IUPAC nos. 138, 153 and 180), HCB, and the organic metabolite of DDT, p,p << -DDE, were analysed with capillary gas chromatography with electron capture detection. Reliability was tested with gas chromatography-mass spectrometry. RESULTS: There were no differences between the study groups of breast-fed and bottle-fed infants with regard to sex distribution, gestational age, birth-weight, age of the mothers, and smoking behaviour of the parents. In contrast, serum concentrations of all organochlorine compounds were significantly higher (P < 0.0001) in breast-fed than in bottle-fed infants (mean): PCB 138, 0.38 vs. 0.10 microg/l; PCB 153, 0.49 vs. 0.1 microg/l; PCB 180, 0.31 vs. 0.04 microg/l; SigmaPCB, 1.19 vs. 0.29 microg/l; HCB, 0.13 vs. 0.04 microg/l; p,p << -DDE, 1.05 vs. 0.18 microg/l. CONCLUSIONS: Breast-feeding significantly increases the pollution of our infants with different organochlorine compounds as early as at 6 weeks of age. The progress of the present study will show whether this pollution will further increase with longer duration of breast-feeding, and whether breast-feeding bears any health risks for our offspring.
G-M Lackmann; K-H Schaller; J Angerer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Science of the total environment     Volume:  329     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-20     Completed Date:  2004-09-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  289-93     Citation Subset:  IM    
Outpatient Paediatric Office, Reinstorfweg 10a, 21107 Hamburg, Germany.
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MeSH Terms
Adipose Tissue
Breast Feeding*
Chromatography, Gas
DDT / blood*,  pharmacokinetics
Environmental Pollutants / blood*,  pharmacokinetics
Hexachlorobenzene / blood*,  pharmacokinetics
Infant Food*
Insecticides / blood*,  pharmacokinetics
Longitudinal Studies
Milk, Human / chemistry*
Polychlorinated Biphenyls / blood*,  pharmacokinetics
Risk Assessment
Reg. No./Substance:
0/Environmental Pollutants; 0/Insecticides; 0/Polychlorinated Biphenyls; 118-74-1/Hexachlorobenzene; 50-29-3/DDT

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