| Organochlorine compounds in breast-fed vs. bottle-fed infants: preliminary results at six weeks of age. | |
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MedLine Citation:
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PMID: 15262173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) are ubiquitous compounds with carcinogenic and teratogenic properties. They are chemically very stable and lipophilic and, therefore, accumulate in our food-chain. They are prenatally transmitted from mother to foetus, and mother's milk due to its high lipid content is an elimination pathway of special importance. Therefore, breast-feeding has been held responsible for elevated concentrations of these organochlorine compounds as well as for harmful effects in children later in life. METHODS: Blood samples (2.5 ml) were taken from each 10 breast-fed and bottle-fed infants at 6 weeks of age. Blood specimens were immediately centrifuged, and serum was stored in glass tubes at -20 degrees C until analysis. Three higher chlorinated PCB congeners (IUPAC nos. 138, 153 and 180), HCB, and the organic metabolite of DDT, p,p << -DDE, were analysed with capillary gas chromatography with electron capture detection. Reliability was tested with gas chromatography-mass spectrometry. RESULTS: There were no differences between the study groups of breast-fed and bottle-fed infants with regard to sex distribution, gestational age, birth-weight, age of the mothers, and smoking behaviour of the parents. In contrast, serum concentrations of all organochlorine compounds were significantly higher (P < 0.0001) in breast-fed than in bottle-fed infants (mean): PCB 138, 0.38 vs. 0.10 microg/l; PCB 153, 0.49 vs. 0.1 microg/l; PCB 180, 0.31 vs. 0.04 microg/l; SigmaPCB, 1.19 vs. 0.29 microg/l; HCB, 0.13 vs. 0.04 microg/l; p,p << -DDE, 1.05 vs. 0.18 microg/l. CONCLUSIONS: Breast-feeding significantly increases the pollution of our infants with different organochlorine compounds as early as at 6 weeks of age. The progress of the present study will show whether this pollution will further increase with longer duration of breast-feeding, and whether breast-feeding bears any health risks for our offspring. |
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Authors:
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G-M Lackmann; K-H Schaller; J Angerer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Science of the total environment Volume: 329 ISSN: 0048-9697 ISO Abbreviation: Sci. Total Environ. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-20 Completed Date: 2004-09-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0330500 Medline TA: Sci Total Environ Country: Netherlands |
Other Details:
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Languages: eng Pagination: 289-93 Citation Subset: IM |
Affiliation:
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Outpatient Paediatric Office, Reinstorfweg 10a, 21107 Hamburg, Germany. gmlackmann.praxis@t-online.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue Breast Feeding* Chromatography, Gas DDT / blood*, pharmacokinetics Environmental Pollutants / blood*, pharmacokinetics Female Hexachlorobenzene / blood*, pharmacokinetics Humans Infant Infant Food* Insecticides / blood*, pharmacokinetics Longitudinal Studies Male Milk, Human / chemistry* Polychlorinated Biphenyls / blood*, pharmacokinetics Risk Assessment |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 0/Insecticides; 0/Polychlorinated Biphenyls; 118-74-1/Hexachlorobenzene; 50-29-3/DDT |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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