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Organocatalytic Asymmetric Anti-Selective Michael Reactions of Aldehydes and the Sequential Reduction/Lactonization/Pauson-Khand Reaction for the Enantioselective Synthesis of Highly Functionalized Hydropentalenes.
MedLine Citation:
PMID:  23035862     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A new method has been developed for the enantioselective synthesis of highly functionalized hydropentalenes bearing up to four stereogenic centers with high stereoselectivity (up to 99% ee). This process combines an enantioselective organocatalytic anti-selective Michael addition with a highly efficient one-pot reduction/lactonization/Pauson-Khand reaction sequence. The structures and absolute configurations of the products were confirmed by X-ray analysis.
Authors:
Bor-Cherng Hong; Nitin S Dange; Po-Jen Yen; Gene-Hsiang Lee; Ju-Hsiou Liao
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, R.O.C., and Instrumentation Center, National Taiwan University, Taipei, 106, Taiwan, R.O.C.
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