| Organoammonium hydroselenites: antitumor action through radical balance regulation. | |
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MedLine Citation:
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PMID: 12681434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Organoammonium hydroselenites were synthesized and investigated as potential selective, anticancer prodrugs. These compounds were studied in vitro on human fibrosarcoma (HT-1080), hamster kidney endothelial (BHK 21) and normal mouse embryonic fibroblasts (NIH 3T3). Most of them were very active against HT-1080 (0.6-5.3 g/ml). Amino acid hydroselenites readily increased the nitric oxide (NO) concentration in the culture medium of HT-1080 cells (up to TG(100)=1500%); however, 4-amidohydroximinomethylpyridinium hydroselenite (TG(100)=24%) and o-phenanthrolinium hydroselenite (TG(100)=50%) were free radical inhibitors. All compounds were glutathione peroxidase inhibitors; some of them could also prevent hydrogen peroxide degradation by inhibition of catalase. The influence of the investigated ammonium hydroselenites on tumor cell (HT-1080) morphology was examined. The substances studied were also active in vivo against sarcoma S-180. The role of organoammonium hydroselenites as free radical regulators and their therapeutic antitumor are discussed. |
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Authors:
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Pavel Arsenyan; Irina Shestakova; Kira Rubina; Ilona Domracheva; Alena Nesterova; Kristina Vosele; Olga Pudova; Edmunds Lukevics |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 465 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-08 Completed Date: 2004-02-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 229-35 Citation Subset: IM |
Affiliation:
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Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia. pavel.arsenyan@lycos.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemical synthesis, pharmacology* Catalase / antagonists & inhibitors, metabolism Cell Line, Tumor Cricetinae Drug Screening Assays, Antitumor Endothelium / drug effects, physiology Free Radicals / metabolism Glutathione Peroxidase / antagonists & inhibitors, metabolism Mice Organoselenium Compounds / chemical synthesis, pharmacology* Quaternary Ammonium Compounds / chemical synthesis, pharmacology* Sarcoma 180 / drug therapy Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Free Radicals; 0/Organoselenium Compounds; 0/Quaternary Ammonium Compounds; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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