Document Detail

Organizing activity of wingless protein in Drosophila.
MedLine Citation:
PMID:  8440019     Owner:  NLM     Status:  MEDLINE    
The adult appendages of Drosophila are formed from imaginal discs, sheets of epithelial cells that proliferate during larval development and differentiate during metamorphosis. wingless (wg, DWnt-1) protein, a putative signaling molecule, is expressed only in prospective ventral cells in each of the leg discs. To test the role of wg, we have generated randomly positioned clones of cells that express wg protein constitutively. Clones that arise in the prospective ventral portions of the leg discs develop normally. In contrast, dorsally situated clones give rise to ventrolateral patterns and exert a ventralizing influence on neighboring wild-type tissue. We propose that wg protein organizes leg pattern along the dorsoventral axis by conferring ventral positional information within the disc.
G Struhl; K Basler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  72     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-01     Completed Date:  1993-04-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  527-40     Citation Subset:  IM    
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032.
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MeSH Terms
Base Sequence
Drosophila Proteins*
Drosophila melanogaster / embryology*,  genetics
Embryonic Induction
Extremities / embryology*
Gene Expression Regulation
Genes, Insect
Molecular Sequence Data
Oligodeoxyribonucleotides / chemistry
Proto-Oncogene Proteins / physiology*
Wnt1 Protein
Reg. No./Substance:
0/Drosophila Proteins; 0/Oligodeoxyribonucleotides; 0/Proto-Oncogene Proteins; 0/Wnt1 Protein; 0/wg protein, Drosophila

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