| Organization of the variant domains of alpha satellite DNA on human chromosome 21. | |
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MedLine Citation:
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PMID: 8411206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The de novo creation of long, homogeneous, satellite DNA domains was postulated previously to occur by saltatory amplification. In this paper, pulsed field gel electrophoresis analysis of the alpha satellite DNA block organization of the human chromosome 21 supports this hypothesis. Double-dimension electrophoresis indicated that the variant copies of the basic alpha satellite repeat of chromosome 21 are organized in a single 3,150 Kb-long domain. It was also established that the other satellite DNAs found in man (beta, II, and III) are organized independently of the alpha satellite DNA block of the same chromosome. |
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Authors:
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B Marçais; A M Laurent; J P Charlieu; G Roizès |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of molecular evolution Volume: 37 ISSN: 0022-2844 ISO Abbreviation: J. Mol. Evol. Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-11-10 Completed Date: 1993-11-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0360051 Medline TA: J Mol Evol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 171-8 Citation Subset: IM |
Affiliation:
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Institut de Biologie, U. 249 INSERM, LP 8402 CNRS, Montpellier, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence Chromosomes, Human, Pair 21* DNA, Satellite / genetics*, isolation & purification Electrophoresis, Gel, Pulsed-Field Evolution Female Gene Amplification Genetic Variation* Genetics, Population Genome, Human Humans Male Molecular Sequence Data Pedigree Polymorphism, Genetic Repetitive Sequences, Nucleic Acid |
| Chemical | |
Reg. No./Substance:
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0/DNA, Satellite |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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