| Organization of the resting TCR in nanoscale oligomers. | |
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MedLine Citation:
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PMID: 23278737 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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SUMMARY: Despite the low affinity of the T-cell antigen receptor (TCR) for its peptide/major histocompatibility complex (pMHC) ligand, T cells are very sensitive to their antigens. This paradox can be resolved if we consider that the TCR may be organized into pre-existing oligomers or nanoclusters. Such structures could improve antigen recognition by increasing the functional affinity (avidity) of the TCR-pMHC interaction and by allowing cooperativity between individual TCRs. Up to approximately 20 TCRs become tightly apposed in these nanoclusters, often in a linear manner, and such structures could reflect a relatively generalized phenomenon: the non-random concentration of membrane receptors in specific areas of the plasma membrane known as protein islands. The association of TCRs into nanoclusters can explain the enhanced kinetics of the pMHC-TCR interaction in two dimensional versus three dimensional systems, but also their existence calls for a revision of the TCR triggering models based on pMHC-induced TCR clustering. Interestingly, the B-cell receptor and the FcεRI have also been shown to form nanoclusters, suggesting that the formation of pre-existing receptor oligomers could be widely used in the immune system. |
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Authors:
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Wolfgang W A Schamel; Balbino Alarcón |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunological reviews Volume: 251 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: England |
Other Details:
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Languages: eng Pagination: 13-20 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Affiliation:
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Department of Molecular Immunology, Institute of Biology III, Faculty of Biology, BIOSS Centre for Biological Signaling Studies, University of Freiburg; and Centre for Chronic Immunodeficiency CCI, University Clinics Freiburg, Freiburg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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