Document Detail


Organization of permanent and transient neuropeptide Y-immunoreactive neuron groups and fiber systems in the developing hamster diencephalon.
MedLine Citation:
PMID:  7673485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of neuropeptide Y-immunoreactive (NPY-IR) cell and fiber systems in the hamster diencephalon was studied. Eight perinatal groups of NPY-IR neurons develop into 12 distinct sets in nuclei of the adult diencephalon and mesencephalon. NPY-IR neurons of the thalamic precommissural nucleus, nucleus of the optic tract, and olivary pretectal nucleus are derived from the superior group. Those in the adult magnocellular nucleus of the posterior commissure and deep mesencephalic nucleus are from the dorsal group. An arcuate group contributes neurons to the arcuate nucleus and median eminence and a mammillary group transiently exists in the mammillary region. A medial group gives rise to two sets of neurons, one that migrates to the intergeniculate leaflet and another that develops in the medial nucleus reuniens. A very large ventral group provides NPY-IR neurons to the adult medial zona incerta and caudal reticular thalamus. Groups of NPY-IR neurons also appear in the bed nucleus of the stria terminalis and centromedian thalamic nucleus. Superior group neurons may undergo apoptosis. In several groups, neurons become fewer during development, and NPY-IR may disappear. NPY-IR neurons of several groups initially migrate away from the neuroepithelial zone with later emergence of a distinct, persistent set of NPY-IR neurons in the same neuroepithelial region. The data show that neuropeptide content can be used to identify particular sets of neurons early in development, thereby allowing migration patterns to be followed and principles of brain development to be elucidated.
Authors:
G I Botchkina; L P Morin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  357     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-10-19     Completed Date:  1995-10-19     Revised Date:  2011-03-08    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-602     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, School of Medicine, State University of New York, Stony Brook 11794, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cricetinae
Diencephalon / chemistry,  cytology*,  embryology
Hypothalamus / cytology
Immunohistochemistry
Mesocricetus / anatomy & histology*,  embryology,  metabolism
Neurons / chemistry*
Neuropeptide Y / analysis*
Thalamus / cytology
Time Factors
Grant Support
ID/Acronym/Agency:
NS22168/NS/NINDS NIH HHS; R01 NS022168-15/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Neuropeptide Y

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