Document Detail


Organization of the neural switching circuitry underlying reflex micturition.
MedLine Citation:
PMID:  23033877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain and spinal cord that coordinates the activity of the bladder and urethral outlet. Experimental studies in animals indicate that urine storage is modulated by reflex mechanisms in the spinal cord, whereas voiding is mediated by a spinobulbospinal pathway passing through a coordination centre in the rostral brain stem. Many of the neural circuits controlling micturition exhibit switch-like patterns of activity that turn on and off in an all-or-none manner. This study summarizes the anatomy and physiology of the spinal and supraspinal micturition switching circuitry and describes a computer model of these circuits that mimics the switching functions of the bladder and urethra at the onset of micturition.
Authors:
W C de Groat; C Wickens
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-10-24
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  207     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-12     Completed Date:  2013-07-02     Revised Date:  2013-07-25    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  66-84     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.
Affiliation:
Department of Pharmacology and Chemical Biology, University of Pittsburgh Medical School, Pittsburgh, PA 15261, USA. wcd2@pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Nervous System / anatomy & histology*,  physiology*
Humans
Reflex / physiology*
Urethra / innervation,  physiology
Urinary Bladder / innervation*,  physiology*
Urination / physiology*
Grant Support
ID/Acronym/Agency:
DK 091253/DK/NIDDK NIH HHS; R01 DK091253/DK/NIDDK NIH HHS
Comments/Corrections

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