Document Detail


Organization of myelin in the mouse somatosensory barrel cortex and the effects of sensory deprivation.
MedLine Citation:
PMID:  23047707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In rodents, the barrel cortex is a specialized area within the somatosensory cortex that processes signals from the mystacial whiskers. We investigated the normal development of myelination in the barrel cortex of mice, as well as the effects of sensory deprivation on this pattern. Deprivation was achieved by trimming the whiskers on one side of the face every other day from birth. In control mice, myelin was not present until postnatal day 14 and did not show prominence until postnatal day 30; adult levels of myelination were reached by the end of the second postnatal month. Unbiased stereology was used to estimate axon density in the interbarrel septal region and barrel walls as well as the barrel centers. Myelin was significantly more concentrated in the interbarrel septa/barrel walls than in the barrel centers in both control and sensory-deprived conditions. Sensory deprivation did not impact the onset of myelination but resulted in a significant decrease in myelinated axons in the barrel region and decreased the amount of myelin ensheathing each axon. Visualization of the oligodendrocyte nuclear marker Olig2 revealed a similar pattern of myelin as seen using histochemistry, but with no significant changes in Olig2+ nuclei following sensory deprivation. Consistent with the anatomical results showing less myelination, local field potentials revealed slower rise times following trimming. Our results suggest that myelination develops relatively late and can be influenced by sensory experience.
Authors:
Kyrstle Barrera; Philip Chu; Jason Abramowitz; Robert Steger; Raddy L Ramos; Joshua C Brumberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-26
Journal Detail:
Title:  Developmental neurobiology     Volume:  73     ISSN:  1932-846X     ISO Abbreviation:  Dev Neurobiol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-11     Completed Date:  2013-08-23     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101300215     Medline TA:  Dev Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-314     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Data Interpretation, Statistical
Evoked Potentials / physiology
Evoked Potentials, Somatosensory / physiology
Female
Histocytochemistry
Immunohistochemistry
Male
Mice
Myelin Basic Protein / biosynthesis,  genetics
Myelin Sheath / physiology*
Neocortex / growth & development,  physiology
Oligodendroglia / metabolism,  ultrastructure
Sensory Deprivation / physiology*
Somatosensory Cortex / growth & development,  physiology*
Vibrissae / innervation,  physiology
Grant Support
ID/Acronym/Agency:
NS058758/NS/NINDS NIH HHS; R01 NS058758/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Myelin Basic Protein
Comments/Corrections

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