Document Detail


Organization of food protection behavior is differentially influenced by 192 IgG-saporin lesions of either the medial septum or the nucleus basalis magnocellularis.
MedLine Citation:
PMID:  18823954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Converging lines of evidence have supported a role for the nucleus basalis magnocellularis (NB) in attentional mechanisms; however, debate continues regarding the role of the medial septum in behavior (MS). Recent studies have supported a role for the septohippocampal system in the online processing of internally generated cues. The current study was designed to investigate a possible double dissociation in rat food protection behavior, a natural behavior that has been shown to depend on external and internal sources of information. The study examined the effects of intraparenchymal injections of 192 IgG-saporin into either the MS or NB on the organization of food protection behavior. NB cholinergic lesions reduced the number of successful food protection behaviors while sparing the temporal organization of food protection behavior. In contrast, MS cholinergic lesions disrupted the temporal organization of food protection behavior while sparing the ability to successfully protect food items. These observations are consistent with a double dissociation of NB and MS cholinergic systems' contributions to processing external and internal sources of information and provide further evidence for the septohippocampal system's involvement in processing internally generated cues.
Authors:
Megan M Martin; Shawn S Winter; Joseph L Cheatwood; Lynniece A Carter; Jeana L Jones; Scott L Weathered; Steven J Wagner; Douglas G Wallace
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-09-16
Journal Detail:
Title:  Brain research     Volume:  1241     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-01-26     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  122-35     Citation Subset:  IM    
Affiliation:
Department of Psychology, Northern Illinois University, De Kalb, IL 60115-2892, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / metabolism*
Animals
Antibodies, Monoclonal
Attention / physiology
Basal Nucleus of Meynert / physiology*
Behavior, Animal / physiology
Cholinergic Fibers / physiology*
Cognition / physiology
Cues
Denervation
Feeding Behavior / physiology*
Female
Fornix, Brain / physiology
Hippocampus / physiology
Immunotoxins
Neural Pathways / physiology
Parvalbumins / metabolism
Rats
Rats, Long-Evans
Rats, Sprague-Dawley
Ribosome Inactivating Proteins, Type 1
Septal Nuclei / physiology*
Social Behavior*
Grant Support
ID/Acronym/Agency:
NS051218/NS/NINDS NIH HHS; R15 NS051218-01A1/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/192 IgG-saporin; 0/Antibodies, Monoclonal; 0/Immunotoxins; 0/Parvalbumins; 0/Ribosome Inactivating Proteins, Type 1; 51-84-3/Acetylcholine
Comments/Corrections

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